SHAFT has some pretty epic anime in their arsenal. They've done Negima!?, Pani Poni Dash!, Sayonara Zetsubou Sensei, to name a few. One of their newest creations is called "Maria†Holic". I stumbled upon it because I downloaded the OP and ending, because I adore Yuu Kobayashi.
Maria Holic revolves around a high school girl, Kanako Miyamae, who is scared of boys and breaks out in hives if a boy touches her. During her second year of high school, she enrolls in an all-girls school hoping to find a female romantic partner. However, her ideal candidate, Mariya Shidō, turns out to be a crossdressing boy.
I know. "LOLWHUT?" But! Before you judge, let me tell you it is quite amazing. My signature and avatar are from the OP.
There are 12 episodes, and id ongoing. And the manga ran for 4 volumes.
The main characters are:
Kanako Miyamae (宮前かなこ)
Kanako is the protagonist of the story. She is a second year high school transfer student to Ame no Kisaki. When a boy touches her, she breaks out in hives, giving her a fear of boys.
(Seiyuu: Asami Sanada)
Mariya Shidou (祇堂鞠也)
Mariya is a boy who crossdresses, attending Ame no Kisaki as a girl to find a wife, where his grandmother is the ex-chairman. When Kanako first met him, she liked him because of his lovely, kind attitude. However, he is actually quite sadistic. He has a twin sister who pretends to be a boy and goes to boys' school. (Ep. 6)
(Seiyuu: Yuu Kobayashi)
Matsurika Shinouji (汐王寺茉莉花)
Matsurika is Mariya's maid who is generally silent, but can be rude. She calls Kanako names such as "Ms. Pig" or Eiffel Tower due to her tall stature.
(Seiyuu: Marina Inoue)
Dorm Leader (寮長先生)
The neko-mimi (cat-eared) dorm head of Ame no Kisaki's Second Girls Dormitory.
As the appointed dorm head she is in charge of nearly everything from cleaning to preparing meals. She even made a 13 volume, 36 hour long video collection entitled "Living in the Dorms is Dangerous: The Rules of the Second Girls Dormitory" explaining the rules of the dorm & anyone who breaks the rules is forced to watch it without exception.
She is always accompanied by Yonakuni-san, the apron wearing dorm watchdog.
(Seiyuu: Miyuki Sawashiro)
All the other seiyuu are well known ones as well (Ryoko Shintani, Aya Hirano, Akemi Kanda, ect.)
If you can't tell this OP is by SHAFT, then you must be a pure-bred twit.
OP "Hanaji" by Yuu Kobayashi
I can't find the ending, but here's an adorable preview sort of thing featuring the dorm head.