Tadayasu Sawaki was born with an unique ability: He can see and communicate with bacteria and other micro-organisms - in fact they consider him to be their friend and are quite noisy. Together with his childhood friend, Kei, he starts a new year off as a first-year student at an Agricultural College. But none of his experiences so far could prepare him for college life!!

As this is an ‘educational’ anime series, the last 90 seconds of each episode is devoted to a `microbe theater` which has various micro-organisms explain who they are and what they do.