Spice and Wolf (狼と香辛料 Ōkami to Kōshinryō?, lit. Wolf and Spice) adaptation produced by the animation studio Imagin aired in Japan between January 9 and March 26, 2008 on the Chiba TV Japanese television network; twelve of the thirteen episodes were broadcast, with episode seven being a DVD exclusive.
(Source - Wiki)
Plot Summary: Kraft Lawrence, a 25 year old peddler travelling from town to town selling and buying various things to make a living during a period much like Europe in the Middle Ages. One night when stopped at the town of Pasroe, he finds in his wagon a 250 year old pagan wolf deity girl named Holo. She appears to be that of a 15 year old girl, except for a wolf tail and ears. She introduces herself as the town's goddess of harvest who has kept it blessed with good harvests of wheat for many years. Despite having the responsibility to watch over the town, she wants to go back to her homeland in the north called Yoitsu, she believes the people have already forsaken her anyway and that she has kept her promise to maintain the good harvests. She manages to bargain her way out of the village by making a deal with Lawrence to take her with him. As they travel, her wisdom helps increase his profits, but at the same time, her true nature draws unwanted attention from the church.
Genres: adventure, drama, fantasy, romance, supernatural
Themes: economics, trading, wolf girls
Age Rating: Older Teen
(Source - ANN)
I've only seen a few episodes so far, but it seems really good. It's also had a few articles in Newtype.
Spice and Wolf on Wikipedia
The Official Website
Spice and Wolf on Anime News Network
The Opening and Ending
I personally think the ending sequence sounds silly, because of the Japanese singing English.
I didn't see a topic for this anime already, so if there is one sorry about that .__.