Finally, the best of, well...everything. Like in most awards, these titles have popped up again and again in the other categories, so it should come as no surprise to see them here as well. If you've read the other award threads (mei recommends that you check them out before voting in this category), you're probably familiar with those ANN blurbs, so mei won't quote or link anything here.
Without further ado~
The Melancholoy of Haruhi Suzumiya
Ouran Koukou Host Club