Right now I just want to see someone do a lengthy series based on White Wolf's 'World of Darkness' rpgs. I've been playing VTMB a lot lately, and it really strikes me as a great setting for a really dark, violent and ribald show. The main character could be a vampire just inducted into the ranks, and now seeks to discover a cure for his 'condition.'
Yes, it's not an original idea, but it's all I could come up with on short notice.
I'll think of a better one later.
...now you try.