well actually about half the homunculi were different.
sloth, like you said, was this really creepy, muscley dude in the manga and was ed and al's mom in the anime
pride was the the kind bradley's son in the manga and bradley in the anime
wrath was bradley in the manga and izumi's child in the anime
personally i think that lust was the most different that both ways have. in the manga she was really evil-ish. in the anime, she changed and became good.
you little liar you are God :]by the way, i am a girl no matter what the profile thing on the side says